European Oocyte Biology Research Innovation Training Net

01 November 2019 → 31 October 2024
European funding: framework programme
Research disciplines
  • Medical and health sciences
    • Developmental biology
    • Epigenetics
    • Reproductive medicine
  • Agricultural and food sciences
    • Veterinary embryology
    • Veterinary genetics
    • Veterinary reproduction and obstetrics
Oocyte Biology
Other information
Project description

The hallmark of successful mammalian reproduction is the fusion between a haploid spermatozoon and a metaphase II oocyte. The generation of such an oocyte involves a series of steps whereby germinal-vesicle oocytes (in which the nuclei are intact) at prophase I are stimulated to resume meiosis and mature to metaphase II, a sequence of events that prepares the oocyte for fertilization. Although the treatment of infertility by Assisted Reproduction Technologies (ART) has been increasingly successful, the efficiency remains low with only about 1 in 10 eggs retrieved from women undergoing infertility treatments healthy enough to produce a pregnancy and birth. In healthy fertile livestock species, where ARTs are applied for production purposes this number increases to 1 in 6 eggs retrieved, which is still remarkably inefficient. The greatest block to advancement, is the substantial lack of knowledge on the key regulatory checkpoints and processes that determine oocyte health. Such knowledge is key not just to treating infertility and maximising livestock genetic potential and productivity, but also to the field of regenerative medicine, where the reprogramming potential of the oocyte cytoplasm is critical to reprogramming somatic genomes. The EUROVA ETN will train a consolidate European Oocyte Biology Research, train a new cohort of Reproductive scientists and generate new knowledge. A deeper knowledge and understanding of the mechanisms set in place during the trajectory of oocyte growth, maturation, fertilization and oocyte to zygote transition will lead to innovations in ART, animal breeding, endangered species preservation, regenerative medicine and reproductive toxicology.

Role of Ghent University
Ghent will be supervising two ESRs on oocyte maturation in vitro. Ann Van Soom is also the WP4 leader : WP4 is dedicated to dissemination, communication and exploitation of the EUROVA project results and activities. To define and establish suitable communication and exploitation actions that EUROVA will undertake to ensure its success and sustainability
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency (REA). Neither the European Union nor the authority can be held responsible for them.