Project

Determinating the master transcription factors driving Kupffer cell differentiation,

Code

3E000916

Looptijd

01-10-2016 → 30-09-2019

Financiering

Research Foundation - Flanders (FWO)

Promotor

Martin Guilliams

Fellow

Johnny Bonnardel

Onderzoeksdisciplines

Natural sciences
- Bioinformatics of disease
- Infectious diseases
Medical and health sciences
- Bio-informatics and computational biology not elsewhere classified

Trefwoorden

Lever Kupffer Cellen Macrofagen Transcriptie factoren

Projectomschrijving

Genetic profiling of macrophages from various tissues has demonstrated their astonishing diversity, suggesting that each macrophages is profoundly adapted to its tissue of residence. We propose to identify the liver macrophages specific transcription factors and utilize genetically modified mice to specifically silence these transcription factors in liver macrophages. This approach should highlight wich factors drive the development of these cells.