Code
01SB1409
Duration
01 January 2009 → 31 October 2011
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Molecular and cell biology
- Molecular and cell biology
Keywords
forkhead transcription factor
human developmental disease
FOXL2
BPES
Project description
A first aim is the development of a functional assay for intragenic FOXL2 mutations, for predictive testing for ovarian dysfunction in BPES. A second aim is the identification of the genetic defect in BPES patients without an intragenic mutation, gene deletion or large long-range genetic defect, and functional studies of potential regulators of FOXL2 transcription.