This project aims at developing a highly sensitive sensing platform for early detection of sepsis. To push the boundaries of sensitivity towards recognition of single biomarker binding events, noncovalent supramolecular modification of a graphene sensing platform with aaptamer receptors will be developed. The perfection of graphene minimizes background noise while non-covalent modification is required to not disturb the electronic properties of graphene. The final part of the project focuses on further modification of the sensor platform with hydrophilic polymers to suppress non-specific protein adsorption, thereby further enhancing the selectivity of the sensors.