Project

The role of microRNA's in the pathogenesis of T-cell acute lymphoblastic leukemia

Code

3E019108

Duration

01 October 2008 → 30 September 2014

Funding

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Franki Speleman

Research disciplines

Natural sciences
- Genetics
- Systems biology
Medical and health sciences
- Molecular and cell biology
- Molecular and cell biology

Keywords

T-cell leukemia array-CGH miRNA profiling

Project description

MicroRNAs are a recently discovered class of small (22nt) endogenously expressed translational repressor RNAs that play key roles in many cellular pathways. In this project, we aim to investigate the role of deregulated miRNA expression in the pathogenesis of T-cell acute lymphoblastic leukemia using a new PCR-based stem-loop method, in which the expression of 500 miRNAs can be dtermined in a single multiplex analysis.