Project

Elucidation of the genetic defect in sporadic melorheostosis and study of the precise role of LEMD3 in bone homeostasis

Duration
01 January 2009 → 31 December 2012
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
Keywords
transgenic mouse LEMD3 melorheostosis interactions TGFbeta/BMP signaling osteopoikilosis
 
Project description

This project aims to identify the genetic defect in sporadic melorheostosis. In addition we aim to gain more insights into the precise role of LEMD3 in TGFbeta/BMP signaling and regulation of bone density. For this study we will use several approaches including yeast two hybrid experiments, ChIP-seq, a transgenic mouse model and whole-exome sequencing.