Code
01D28908
Duration
01 January 2009 → 31 December 2012
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
Keywords
transgenic mouse
LEMD3
melorheostosis
interactions
TGFbeta/BMP signaling
osteopoikilosis
Project description
This project aims to identify the genetic defect in sporadic melorheostosis. In addition we aim to gain more insights into the precise role of LEMD3 in TGFbeta/BMP signaling and regulation of bone density. For this study we will use several approaches including yeast two hybrid experiments, ChIP-seq, a transgenic mouse model and whole-exome sequencing.