Two well-known optimisation problems, project portfolio selection and multi-project scheduling are often only treated as separate, sequential problems. By integrating both problems into one decision making system, it is possible to select and schedule projects that fit the organisation’s resource profile. The benefits of this integrated approach are augmented by integrating the existence of project interdependencies as a key extension. Two projects are interdependent when the selection and/or scheduling of one project influences the other project. This research proposal consists of four studies. A first study benchmarks the existing solution procedures for the multi-project scheduling problem. A second study integrates both problems, includes project interdependencies and develops effective solution strategies. A third step considers the dynamic problem by analysing arriving projects in the portfolio. Finally, stochasticity will be introduced in the model and its effectiveness to handle it will be analysed.