In depth insight into the translatome using state-of-the-art proteomics and ribosome profiling, applications on different in vitro model systems.

01 October 2015 → 30 September 2019
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Applied mathematics in specific fields
    • Computer architecture and networks
    • Distributed computing
    • Information sciences
    • Information systems
    • Programming languages
    • Scientific computing
    • Theoretical computer science
    • Visual computing
    • Other information and computing sciences
    • Animal biology
    • Bioinformatics and computational biology
    • Genetics
  • Medical and health sciences
    • Bioinformatics and computational biology
    • Morphological sciences
    • Oncology
    • Bioinformatics and computational biology
    • Morphological sciences
    • Oncology
    • Public health care
    • Public health services
    • Bioinformatics and computational biology
    • Morphological sciences
    • Oncology
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
    • Scientific computing
  • Agricultural and food sciences
    • Veterinary medicine
proteomics organoid bodies cell lines translation control ribosome profiling mass spectrometry bioinformatics translation proteogenomics embryoid bodies
Project description

From a proteogenomic approach, bioinformatic tools will be developped to combine ribosome profiling and mass spectrometry results. These tools will secure exhaustive analysis of different translation features and controls. Experiments will be performed in cell lines and afterwards in embryoid and organoid bodies, as a proxy to in vivo tissue.