Cancer, with an annual mortality rate wordlwide of around 8 million, poses challenges in the development of efficient treatment systems. Complicating this scenario are cancer models that do not perfectly mimic the reality of the tumor. This, upon the invention of novel strategies, obstructs their smooth transition into the market. In this study, we will try to tackle these challenges by development of versatile platform based on crosslinked alginate materials, which will be combined with drug delivery system for a cancer treatment, while offering an option to be used as an innovative 3D-cancer model. The therapeutic system involves hydrogel patches and injectable hydrogels with an encapsulated particle-based smart drug delivery system, ensuring localized treatment, controlled release, and reduced systemic exposure. The 3D cancer model is designed to gradually stiffen, mimicking real tumor conditions linked to increasing oxidative environment common to the cancer growth, to enhance the model's relevance. The materials are 3D-printable, enabling the creation of porous scaffolds—an imperative factor for the invasion and migration of the tumor. The developed materials include a diagnostic modality, crucial for monitoring the in vivo fate and ensuring optimal clinical outcomes. This approach aims to tackle the complexities of cancer treatment, from efficient therapeutic systems to advanced 3D cancer models, contributing to progress in the field and improving patient outcomes.