Research Explorer

Project

Characterisation of the physiological role of the NF-kB inhibitor A20 via genetic modification in mice
Code
31504308
Duration
01 January 2008 → 30 December 2012
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
Keywords
signal transduction transgenetics inflammation
 
Project description
 

A20 is a protein that functions as a negative regulator of NF-kB mediated gene expression and inflammation. To understand the role of this protein in the development of inflammatory diseaeses, we will use mouse trangenesis to generate mice that lack the A20 gene in specific tissues. These mice will we analyzed in different mouse models for inflammatory disease.