Project

DNA complexation using amphiphilic cationic molecules

Code
01T01307
Duration
01 December 2007 → 31 March 2009
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Process engineering
    • Polymeric materials
Keywords
nuclear transport gene therapy dna
 
Project description

By organic synthesis aphiphilic molecules are prepared with the ability to form hydrophobic multimolecular complexes with DNA. Their efficiency with respect to itact transport of DNA into the cellular nucleus will be evaluated using biophysical techniques such as FRAP, DLS, FCS and Single Particle Tracking.