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Project

The role of peroxisomes in the inflammatory responses

Outputs and Outcomes

Code

3G067512

Duration

01 January 2012 → 31 December 2017

Funding

Research Foundation - Flanders (FWO)

Promotor

Claus Bachert

Research disciplines

Medical and health sciences
- Immunology
- Respiratory medicine
- Immunology
- Respiratory medicine
- Immunology
- Respiratory medicine

Keywords

β-oxidation lipids peroxisomes

Project description

Peroxisomes are cellular organnelles that perform the formation and breakdown of certain lipids. We hypothezise that peroxisomal β-oxidation could interfere with immune responses. Therefore the role of peroxisomal metabolism in model systems of neuroinflammation, chronic airway inflammation and sepsis will be analyzed. We will use generalized and conditional knockout mice lacking MFP2, an essential enzyme of peroxisomal β-oxidation.

English

Dutch

English

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