Project

Therapeutic restoration of p53 function in neuroblastoma

Duration
01 October 2014 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Keywords
p53 Neuroblastome
 
Project description

Our central research hypothesis is that targeted reactivation of the p53 pathway could provide a new treatment option for patients with neuroblastoma. We will preclinically evaluate combination therapies with the MDM2 inhibitor RG7388, attempt to start a pediatric phase I clinical trial with RG7388, preclinically examine mutant p53 reactivating compounds, and explore p53-targeting miRNAs as a possible new therapeutic target.