Project

The epigenetic regulation of gene expression provided by DNA methylation plays an important role in microbial biofilm resistance and tolerance: mechanistic insights and the road to future pharmacological interventions    

Duration
01 October 2016 → 30 September 2020
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
Keywords
DNA methylation Biofilm resistence
 
Project description

The hypothesis of my proposal is that regulation of bacterial physiology by epigenetic regulation of gene expression provided by DNA methylation contributes to the decreased susceptibility towards antimicrobial agents observed in bacterial biofilms. With my research I expect to obtain a fundamental understanding of how DNA methylation contributes to biofilm resistance in complex clinical environments, and I aim to provide proof-of-concept that DNA methylation pathways are a useful target for innovative antimicrobial therapy.