Project

A structural and functional study of new microbial and nematode globins

Code

3G024709

Duration

01 January 2009 → 31 December 2014

Funding

Research Foundation - Flanders (FWO)

Promotor

Luc Moens

Research disciplines

Natural sciences
- Biochemistry and metabolism
- Systems biology
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism

Keywords

globins protoglobins globin-coupled sensors C. elegans

Project description

The aim of this study is to establish the physico-chemical characteristics and the molecular structure of unconventional microbial and nematode globins including protoglobins, globin coupled sensors and uncharacterized globins of Caenorhabditis elegans. Experimental approaches will include expression cloning, study of ligand binding, crystallization and X-ray diffraction analysis, and (for C. elegans) GFP reporter constructs, RNAi silencing and identification of potential binding partners.