Project

A structural and functional study of new microbial and nematode globins

Duration
01 January 2009 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
globins protoglobins globin-coupled sensors C. elegans
 
Project description

The aim of this study is to establish the physico-chemical characteristics and the molecular structure of unconventional microbial and nematode globins including protoglobins, globin coupled sensors and uncharacterized globins of Caenorhabditis elegans. Experimental approaches will include expression cloning, study of ligand binding, crystallization and X-ray diffraction analysis, and (for C. elegans) GFP reporter constructs, RNAi silencing and identification of potential binding partners.