Research Explorer

Project

Unraveling the role of PHF6 in normal T cell development and T-cell acute leukemia
Code
31521011
Duration
01 January 2011 → 31 December 2013
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
Keywords
tumor suppressor PHF6 leukemia T-ALL
 
Project description
 

T-cell acute lymphoblastic leukemia (T-ALL) arises from malignant transformation of precursor T-cells and often affects children. In the search for novel genetic defects in this cancer, PHF6 was recently identified as a novel tumor suppressor gene in T-ALL. In this project, the cellular function of PHF6 and its role in normal T-cell development and T-ALL will be investigated.