Project

Exploring molecular mechanisms underlying arrhythmogenic cardiomyopathy using human engineered heart tissue

Code
01CD8322
Duration
16 January 2023 → 15 October 2023
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Cardiology
Keywords
induced pluripotent stem cells engineered heart tissue Arrhythmogenic cardiomyopathy disease modeling
 
Project description

Arrhythmogenic cardiomyopathy is a rare heritable heart muscle disease, characterized by progressive substitution of myocardium by fibro-fatty tissue. Molecular mechanisms underlying this disease remain elusive. In the PhD project of Laurens Léger, engineered heart tissues from patientspecific induced pluripotent stem cells are generated to elucidate early molecular mechanisms.