Project

The role of PHF6 in normal and malign T-cell development.

Duration
01 October 2009 → 30 September 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
Keywords
PHF6 T-ALL genetics
 
Project description

T-ALL is an agressive malignancy that develops in the thymus and is characterized by an uncontrolled division of immature T-cells. Recently, we identified deletions and inactivating mutations of the PHF6 gene in ~20% male T-ALL patients and ~25% male T-ALL cell lines. The exact function of this transcription factor and his role in the development of T-ALL are not known.