Project

Field study on the efficacy of PolyA6-1 to prevent F18+ E. coli disease in newly weaned pigs

Acronym
COLIGO field trials
Code
F2015_IOF STARTT_120
Duration
15 November 2015 → 30 June 2017
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Natural sciences
    • Animal biology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
receptor analogs
 
Project description

Diseases such as teat diarrhea and / or edema disease often occur shortly after weaning. Enterotoxigene (ETEC) or verotoxigenic Escherichia coli (VTEC) that produce F18 fimbriae are a major cause of these diseases that give rise to significant economic losses. These losses are due to mortality, reduced growth and additional costs for medication. The Laboratory of Immunology discovered that F18 + E. coli specifically bind to ABH blood group sugars and that high concentrations of these sugars inhibit in vitro binding of F18 + E. coli to small intestinal villi. It was also shown that the concentration could be reduced 250 times by conjugating these sugars to a protein (HSA) to form multimers. During an IOF-Advanced project, new multimers were produced by a biotech company with expertise in the large-scale production of complex sugars and in the functionalization of sugars. With this project we aim to check the efficiency of the multimere sugar on a company.