Research Explorer

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Project

Towards the structural and molecular basis of pro-inflammatory signalling assemblies mediated by IL-23 and IL-12

Outputs and Outcomes

Publications

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Yehudi BlochJan FélixRomain MerceronMathias ProvostRoyan Alipour SymakaniRobin De BackerElisabeth LambertAhmadreza MehdipourSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Eva ClootsPhaedra GuilbertMathias ProvostLisa NeidhardtEvelien Van De VeldeFarzaneh FayazpourDelphine De SutterSavvas SavvidesSven EyckermanSophie Janssens

A1 Journal Article in EMBO JOURNAL

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy WullaertTino HochepiedEsther HosteLieselotte Vande WalleMohamed LamkanfiSavvas SavvidesDirk ElewautBart LambrechtGeert van Loo et al.

A1 Journal Article in SCIENTIFIC REPORTS

Pore-forming proteins as drivers of membrane permeabilization in cell death pathways

Peter VandenabeeleGeert BultynckSavvas Savvides

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27

Katarzyna SkladanowskaYehudi BlochJamie StrandKerry F. WhiteJing HuaDaniel AldridgeMartin WelinDerek T. LoganArne SoeteRomain MerceronCasey MurphyMathias ProvostJ. Fernando BazanChristopher A. HunterJonathan A. HillSavvas Savvides et al.

A1 Journal Article in CELL REPORTS

Structural basis of cytokine-mediated activation of ALK family receptors

Steven De MunckMathias ProvostMichiko KurikawaIkuko OmoriJunko MukohyamaJan FélixYehudi BlochOmar Abdel-WahabJ. Fernando BazanAkihide YoshimiSavvas Savvides et al.

A1 Journal Article in NATURE

Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting

Erwin PannecouckeMaaike Van TrimpontJohan DesmetTim PietersLindy ReunesLisa DemoenMarnik VuylstekeStefan LoverixKaren VandenbrouckePhilippe AlardPaula HenderikxSabrina DerooFranky BaatzEric LorentSophie ThiolloyKlaartje SomersYvonne McGrathPieter Van VlierbergheIgnace LastersSavvas Savvides et al.

A1 Journal Article in SCIENCE ADVANCES