Research Explorer

Project

IMPORTANCE AND INTERACTION OF ALLERGY, INFECTIONS AND RESPIRATORY ENVIRONMENTAL EXPOSURES IN CHRONIC LOWER & UPPER AIRWAY DISEASES (AIREWAY II consortium)
Code
120C14B12
Duration
01 April 2012 → 31 December 2017
Funding
Federal funding: various
Research disciplines
  • Medical and health sciences
    • Otorhinolaryngology
    • Respiratory medicine
    • Otorhinolaryngology
    • Respiratory medicine
    • Speech, language and hearing sciences
    • Otorhinolaryngology
    • Respiratory medicine
Keywords
damage associated molecular patterns (DAMPs) Transient Receptor Potential (TRP)-channels asthma Pattern Recognition Receptors (PRRs) chronic rhinosinusitis COPD nasal polyps epigenetic changes
 
Project description
 

AIREWAY II, we will further unravel the mechanisms by which allergens, environmental pollutants and microbial agents initiate lower and upper airway diseases and modulate disease persistence. We hypothesize that the following mechanisms -modulated by environmental triggers- play a crucial role in the development of airway diseases: Transient Receptor Potential (TRP)-channels, damage associated molecular patterns (DAMPs), Pattern Recognition Receptors (PRRs), epigenetic changes