Code
3E025110
Looptijd
01-10-2010 → 19-01-2014
Financiering
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Onderzoeksdisciplines
-
Medical and health sciences
- Endocrinology and metabolic diseases
- Gynaecology and obstetrics
- Endocrinology and metabolic diseases
- Gynaecology and obstetrics
- Nursing
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Endocrinology and metabolic diseases
- Gynaecology and obstetrics
Trefwoorden
metabonomics
isoflavonen
transcriptomics
SERM
epigenetica
borst kanker
soja
fyto-oestrogenen
oestrogene responsen
Projectomschrijving
Upon soy consumption, isoflavones reach exposure levels in human breast tissue at which ERβ agonistic, putative protective, effects may occur. Yet, the clinical implications of these findings require further investigation. This project aims to characterize the differential activation of estrogen-responsive genes between dietary isoflavones and chemopreventive therapeutics in women undergoing breast reduction surgery by a controlled dietary intervention trial.