Research Explorer

Project

Cis-regulatory mapping of the RPE-expressed transcription factor OTX2
Acronym
EyeTN
Code
41Q09012
Duration
01 November 2012 → 31 October 2016
Funding
Europese middelen: kaderprogramma
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
Keywords
exoom retinale dystrofie erfelijke blindheid retinaal pigment epitheel cis-regulatorische mapping variant prioritisatie
 
Project description

Corbo et al. (2010) mapped CRX bound cis-regulatory elements in mouse, resulting in a photoreceptor-specific regulatory map. Retinal pigment epithelium (RPE)-expressed genes are not represented in this dataset. ChIP-seq of the RPE-expressed transcription factor OTX2 will be performed in RPE-derived cell lines. Exomes data of index cases with retinal dystrophies (RD) will be filtered against known RD genes, and against CRX, NRL and OTX2 cis-regulatory datasets.