Code
3G007810
Looptijd
01-01-2010 → 31-12-2015
Financiering
Research Foundation - Flanders (FWO)
Promotor
Onderzoeksdisciplines
-
Medical and health sciences
- Neurological and neuromuscular diseases
- Neurophysiology
Trefwoorden
noradrenaline
epilepsie
nervus vagus stimulatie
Projectomschrijving
Vagus nerve stimulation (VNS) is a treatment for epilepsy with an unknown mechanism of action. The role of the locus coeruleus and noradrenergic neurotransmission in VNS will be investigated using neurophysiological techniques, selective brain lesions and noradrenergic antagonists/agonists. Unraveling the mechanism of action of VNS could lead to the optimization of stimulation parameters and efficacy of the treatment.