Project

The role of the locus coeruleus and hippocampal noradrenergic neurotransmission in the anticonvulsive effect of vagus nerve stimulation.

Code
3G007810
Looptijd
01-01-2010 → 31-12-2015
Financiering
Research Foundation - Flanders (FWO)
Onderzoeksdisciplines
  • Medical and health sciences
    • Neurological and neuromuscular diseases
    • Neurophysiology
Trefwoorden
noradrenaline epilepsie nervus vagus stimulatie
 
Projectomschrijving

Vagus nerve stimulation (VNS) is a treatment for epilepsy with an unknown mechanism of action. The role of the locus coeruleus and noradrenergic neurotransmission in VNS will be investigated using neurophysiological techniques, selective brain lesions and noradrenergic antagonists/agonists. Unraveling the mechanism of action of VNS could lead to the optimization of stimulation parameters and efficacy of the treatment.