A Tale of Furan and Nucleic Acids: A journey through the exploration of furan chemistry as a versatile tool for nucleic acid targeting.

01 January 2021 → 30 June 2021
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Supramolecular chemistry
    • Bio-organic chemistry
  • Medical and health sciences
    • Public health sciences not elsewhere classified
  • Engineering and technology
    • General chemical and biochemical engineering not elsewhere classified
Organic chemistry Biological chemistry Medicinal chemistry Chemical biology bioorganic chemistr nucleic acid drug transfection therapy Antisense
Project description

MMbio will bridge the classically separate disciplines of Chemistry and Biology by assembling leading experts from academia and non-academic partners (industry, technology transfer & science communication) to bring about systems designed to interfere therapeutically with gene expression in living cells. Expertise in nucleic acid synthesis, its molecular recognition and chemical reactivity is combined with drug delivery, cellular biology and experimental medicine. This project represents a concerted effort to make use of a basic and quantitative understanding of chemical interactions to develop and deliver oligonucleotide molecules of utility for therapy. Our chemical biology approach to this field is ambitious in its breadth and represents a unqiues opportunity to educate young scientists across sectorial and disciplinary barriers. Training will naturally encompass a wide range of skills, requiring a joint effort of chemists and biologists to introduce young researchers in a structured way to and array of research methodologies that no single research grouping could provide. The incorporation of early-stage and later stag ebiotechnology enterprises ensures that commercialisation of ethodologies as well as the drug development process is covered in this ITN. We hope that MMBio will train scientists able to understand both the biological problem and the chemistry that holds the possible solution and develop original experimental approaches to stimulate European academic and commercial success in this area.