Project

Microbes-4-Immunity: single-cell based sorting and investigation of the functional microbiome in intestinal and extra-intestinal immune homeostasis.

Code

01G03122

Duration

01 January 2022 → 31 December 2026

Funding

Regional and community funding: Special Research Fund

Promotor-spokesperson

Tom Van de Wiele

Research disciplines

Natural sciences
- Bacteriology
- Infectious diseases
Medical and health sciences
- Inflammation

Keywords

Microbiome, auto-immune disorder chronic inflammation immunoregulation epithelial barrier integrity: animal models germfree and gnotobiotic bacterial cell sorting.

Project description

The high incidence of chronic inflammatory and auto-immune disorders in a Western lifestyle is associated with the microbiome. It’s however extremely difficult to identify the functional microbiota, modulating immunodevelopment and -homeostasis. This project will generate new insights in microbehost interactions using a unique combination of flowcytometric cellsorting, access to clinical samples and an in vitro and in vivo technology platform.