Code
01J15517
Duration
01 October 2017 → 30 September 2023
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
Keywords
G protein-coupled receptors
synthetic cannabinoids
synthetic opioids
new psychoactive substances
bio-assay
Project description
New psychoactive drugs (NPS) continously appear on the worldwide drug market. Several NPS classes -amongst which synthetic cannabinoids and synthetic opioids- act via G protein-coupled receptors (GPCRs). This project aims at developing high-throughput screening bio-assays focusing on activity of the NPS, rather than their chemical structure. Improved knowledge on the GPCR signaling mechanisms will be implemented to ameliorate these bioassays.