Research Explorer

Project

Patient-individualized radiotherapy for gynecologic cancer treatment.
Code
bof/baf/4y/2024/01/1044
Duration
01 January 2024 → 31 December 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Radiation therapy
    • Cancer therapy
Keywords
gynecological tumors molecular driven adaptive radiotherapy EBRT brachytherapy personalized treatment
 
Project description
The radiotherapeutic treatment of gynecological tumors can be individualized in several ways, based on:
  • dose,
  • irradiation volumes,
  • indication, and
  • concomitantly administered systemic therapies.

Moreover, the rapid advancements in next-generation sequencing (NGS) and molecular profiling demonstrate that the response to radiotherapy may depend also on these factors. Therefore, extensive research into useful molecular predictive biomarkers (such as PD-L1, P53, and MMR status, among others) is essential. This could pave the way for molecularly driven, personalized treatment aimed at improving treatment outcomes and reducing toxicity.

In addition, further research is needed in:

  • the dosing and indications for radiation in oligometastatic disease,
  • and the use of adaptive treatments that are adjusting RT-fields during therapy.

These developments are crucial to advancing the care of patients with gynecological tumors to a higher level.