Project

Disentangeling of Myc interaction networks by integrated genome-wide bioinformatic analysis of high-throughput transcriptomic and ChIP data.

Code
3E010110
Duration
01 October 2010 → 31 August 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Scientific computing
    • Bioinformatics and computational biology
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Bioinformatics and computational biology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Bioinformatics and computational biology
    • Morphological sciences
    • Oncology
    • Public health care
    • Public health services
    • Bioinformatics and computational biology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
  • Engineering and technology
    • Scientific computing
Keywords
ChIP bioinformatics QPCR ChIP-seq
 
Project description

Abnormal high expression of Myc (MYC/MYCN) transcription factor genes is found in several malignancies. Advanced experimental technologies will be applied to extensively interrogate gene expression and gene-DNA binding. This project aims to lead to a better understanding of the role of Myc in normal development and cancer by identifying which Myc driven genetic programs are deregulated in disease.