Research Explorer

Project

Molecular and functional characterization of the tumor suppressors CYLD and A20 as ubiquitin modulating enzymes
Code
365P4513
Duration
01 January 2013 → 31 December 2016
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
signal transduction ubiquitination cancer
 
Project description
 

Dysregulation of components of the ubiquitin system has been linked to many diseases including cancer. The present project proposal focuses on the de-ubiquitinases CYLD and A20, which have been established as tumor suppressors, and aims to dissect the precise molecular mechanisms that regulate and mediate their activity.