Project

Differentiation of COX-2-dependent and -independent VEGF induction in mouse tumors and human colorectal carcinoma and its association with malignancy and sensitivity to anti-angiogenic therapy

Code

3G004308

Duration

01 January 2008 → 30 December 2013

Funding

Research Foundation - Flanders (FWO)

Promotor

Johan Grooten

Research disciplines

Medical and health sciences
- Gastro-enterology and hepatology
- Morphological sciences
- Oncology
- Gastro-enterology and hepatology
- Morphological sciences
- Oncology
- Gastro-enterology and hepatology
- Morphological sciences
- Oncology

Keywords

VEGF COX colorectal cancer

Project description

PGE2 produced by COX2 promotes tumor vascularization through the induction of angiogenic factors such as VEGF. Analysis of mouse tumor models revealed the induction of VEGF also by COX2-independent pathways. This project intends to validate in human colorectal samples the occurrence of COX2-dependent and -independent VEGF expression, their relevance for prognosis and consequences for angiostatic therapy.