Project

Multi-omics data integration in the context of regulatory networks to decipher regulatory metabolites in complex diseases such as cancer and neuro-inflammatory disorders

Code

01D28520

Duration

01 November 2020 → 31 October 2024

Funding

Regional and community funding: Special Research Fund

Promotor

Vanessa Vermeirssen

Fellow

Jens Uwe Loers

Research disciplines

Medical and health sciences
- Bioinformatics data integration and network biology

Keywords

gene regulation transcriptomics epigenomics metabolomics clustering dimensionality reduction network inference machine learning benchmarking

Project description

First, we will conduct a benchmarking of computational methods for multi-omics data integration. Next, we will develop an improved methodology for multi-omics data integration in the context of regulatory networks to gain in-depth mechanistic insights. Finally, we will apply our methodology to neuro-inflammatory disorders and cancer to identify novel regulators such as regulatory metabolites.