Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Project

Study of the interplay between Z-form dsRNA and ADAR1: revealing the mechanisms that prevent autoinflammatory disease and mapping their interaction at the molecular level.

Outputs and Outcomes

Publications

ADAR1 is a central regulator of the dsRNA response : from A-to-Z RNA

Richard de ReuverJonathan Maelfait

Novel insights into double-stranded RNA-mediated immunopathology

Richard de ReuverJonathan Maelfait

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De BruyneElfride De BaereMichiel van GentGuanQun LiuBart LambrechtJens StaalTessa KerreRudi BeyaertJonathan MaelfaitSimon TavernierMichaela U. GackFilomeen Haerynck et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander BotzkiLars VereeckeGeert van LooWim DeclercqSun HurPeter VandenabeeleJonathan Maelfait et al.

A1 Journal Article in NATURE