Research Explorer

Project

GlyConnect: developing glyco-active enzyme reagents for therapeutic glycoprotein functionality enhancement
Acronym
GlyConnect
Code
3S018019
Duration
01 January 2019 → 31 March 2023
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism not elsewhere classified
    • Systems biology not elsewhere classified
  • Medical and health sciences
    • Medical biochemistry and metabolism not elsewhere classified
    • Medical biochemistry and metabolism not elsewhere classified
Keywords
Glycobiology Glycoprotein conjugation protein engineering Antibody drug conjugates
 
Project description
 

In the biopharmaceutical industry, proteins are the main category of biotechnological drugs. To enhace their functionality, often non-protein molecules need to be attached to these proteins. At present, technologies that can do this in a site-specific way without requiring highly expensive chemistry, are in high demand. In this project, we develop such novel technology, through the use of a sugar-specific oxidase to enable coupling to engineered protein-linked glycans.