Research Explorer

Project

Development of a versatile aminoglycoside production platform in Saccharomyces cerevisiae
Code
178LA0515
Duration
01 January 2015 → 31 December 2018
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Engineering and technology
    • Biocatalysis and enzyme technology
    • Bioprocessing, bioproduction and bioproducts
    • Fermentation
    • Industrial microbiology
Keywords
Saccharomyces cerevisiae strains aminoglycosides
 
Project description
 

The aim of this project was twofold. On the one hand, the foundations for an efficient and flexible aminoglycoside production platform were laid as these molecules entail a broad societal impact. On the other hand, different tools and principles for engineering were postulated, leading to an increased production stability in eukaryote synthetic hosts (yeast) as the stability of production hosts on bioreactor scale in industry often poses as a hurdle.