Project

Pathophysiology of the Cartilage Growth Plate

Acronym
EUROGROW
Code
41K03407
Duration
01 May 2007 → 01 May 2010
Funding
European funding: framework programme
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Orthopaedics
    • Orthopaedics
    • Molecular and cell biology
    • Orthopaedics
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
LEMD3 transgenic mouse growth plate osteopoikilosis skeletal dysplasia
 
Project description

Multicentric study of several ransgenic mouse models for human osteochondrodysplasias (achondroplasia, Ellis van-Creveld dysplasia, osteopoikilosis, diastrophic dysplasia, neurofibromatosis type I). The principle objective is to determine the molecular, cell and extracellular matrix pathology of a number of distinct skeletal dysplasia phenotypes by studying a series of mouse models using a multidisciplinary systems biology approach.