Project

The role of Nef induced genes in HIV in infectivity

Code
3F015510
Duration
01 October 2010 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
Keywords
gene expression profiling viral infectivity HIV nef
 
Project description

The HIV Nef protein plays een essential role in progression towards AID. An analysis of expression profiles induced by different Nef alleles in cell lines points to changes in gene expression as a possible mechanism of pathogenicity. The relevance of modulated expression of some genes will be analysed, aiming at discovering mechanisms by which Nef promotes viral infection and pathogenesis.