Research Explorer

Project

Diagnostic and therapeutic consequences of mucosal lymphoid accumulation and local IgE in the nose
Code
01N02110
Duration
01 February 2010 → 30 September 2015
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology
    • Medical imaging and therapy
    • Otorhinolaryngology
    • Respiratory medicine
    • Immunology
    • Medical imaging and therapy
    • Otorhinolaryngology
    • Respiratory medicine
    • Speech, language and hearing sciences
    • Immunology
    • Medical imaging and therapy
    • Otorhinolaryngology
    • Respiratory medicine
Keywords
nasal polyps lymphoid accumulations immunoglobulins
 
Project description

The local production of immunoglobulin’s are dependent of mucosal lymphoid accumulations and determine the severity of nasal polyposis. The role of receptor revision and local class switching are investigated. The diagnostic and therapeutic relevance will be assessed by in-vivo scintigraphy with 99mTc-labled anti-CD20 (B-cell) and 99mTc-labled IL-2 (T-cell) after surgery or specific therapies (anti-IgE, anti-IL-5 and anti-CD20).