Research Explorer

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Project

MOLECULAR DESIGN OF ‘FROZEN’ APTAMERS: Aptamers with enhanced properties by covalent and non-covalent stabilization using functionalized nucleotides: a combined modelling, NMR and electrochemistry approach

Outputs and Outcomes

Publications

Furan-modified PNA probes for covalent targeting and ligation of nucleic acids

Lessandro De PaepeEnrico CadoniAlex ManicardiAnnemieke Madder

A1 Journal Article in METHODS

Furan-based (photo)oxidation reactions and their application in nucleic acid and protein targeting

Jack BarrGertjan ColpaertEnrico CadoniAnnemieke Madder

A1 Journal Article in METHODS

Synthesis and structure-activity relationship of peptide nucleic acid probes with improved interstrand-crosslinking abilities: application to biotin-mediated RNA-pulldown

Enrico CadoniFrancesca PennatiPenthip MuangkaewJoke ElskensAnnemieke MadderAlex Manicardi

A2 Journal Article in RSC CHEMICAL BIOLOGY

A photosensitized singlet oxygen ( 1 O 2) toolbox for bio-organic applications : tailoring 1 O 2 generation for DNA and protein labelling, targeting and biosensing

Dorien AerssensEnrico CadoniLaure TackAnnemieke Madder

A1 Journal Article in MOLECULES

Novel electrochemiluminescent assay for the aptamer-based detection of testosterone

Rocio CanovasElise DaemsRui CamposSofie SchellinckAnnemieke MadderJosé MartinsFrank SobottKarolien De Wael

A1 Journal Article in TALANTA

Hydrolysis of 5-methylfuran-2-yl to 2,5-dioxopentanyl allows for stable bio-orthogonal proximity-induced ligation

Alex ManicardiEnrico CadoniAnnemieke Madder

A1 Journal Article in COMMUNICATIONS CHEMISTRY

Crosslinker-modified nucleic acid probes for improved target identification and biomarker detection

Joke ElskensAnnemieke Madder

A2 Journal Article in RSC CHEMICAL BIOLOGY

Chemical modification of aptamers for increased binding affinity in diagnostic applications : current status and future prospects

Jan ElskensJoke ElskensAnnemieke Madder

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Visible-light triggered templated ligation on surface using furan-modified PNAs

Alex ManicardiEnrico CadoniAnnemieke Madder

A1 Journal Article in CHEMICAL SCIENCE

Do aptamers always bind? : the need for a multifaceted analytical approach when remonstrating binding affinity between aptamer and low molecular weight compounds

Fabio BottariElise DaemsAnne-Mare de VriesPieter Van WielendaeleStanislav TrashinRonny BlustFrank SobottAnnemieke MadderJosé MartinsKarolien De Wael

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PNA-based microRNA detection methodologies

Enrico CadoniAlex ManicardiAnnemieke Madder

A1 Journal Article in MOLECULES