Project

Mechanisms of arrhythmias in the fibrotic heart: the role of heterogeneous distribution of gap junction protein Cx43, sodium channels and tissue architecture

Duration
01 January 2011 → 31 December 2016
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biomechanics
    • Biophysics
    • Biomechanics
    • Biophysics
    • Biomechanics
    • Biophysics
Keywords
physiological biophysics biomathematics cardiac modelling
 
Project description

Aim of this project is development of a detailed mathematical model of human fibrotic cardiac tissue and its application to study of the role of gap junctions, sodium channels heterogeneities and tissue architecture on the formation of abnormal conduction in the heart. Identification of the mechanisms underlying arrhythmias in fibrotic cardiac tissue.