Research Explorer

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Project

Human stem cell-derived models to unveil mechanisms of impaired myocardial function in Marfan Syndrome

Outputs and Outcomes

Publications

Combinatorial effects of surface plasma-treating and aligning PCL/chitosan nanofibers on the behavior of stem cell-derived cardiomyocytes for cardiac tissue engineering

Laurens LégerSheida AliakbarshiraziPegah ZahedifarJeffrey AaldersPascal Van Der VoortNathalie De GeyterRino MorentJolanda van HengelRouba Ghobeira

A1 Journal Article in APPLIED SURFACE SCIENCE

Photoporation-mediated spatial intracellular delivery of stem cell-derived cardiomyocytes

Laurens LégerChloë De ClercqJeffrey AaldersKiara Van Acker-VerbercktKevin BraeckmansJolanda van Hengel

A2 Journal Article in METHODSX

Modelling Marfan-related cardiomyopathy in vitro using human induced pluripotent stem cells

Jeffrey AaldersJolanda van HengelJulie De Backer

Generation of human induced pluripotent stem cell line UGENTi001-A from a patient with Marfan syndrome carrying a heterozygous c.7754 T > C variant in FBN1 and the isogenic control UGENT001-A-1 using CRISPR/Cas9 editing

Jeffrey AaldersLaurens LégerAnthony DemolderLaura Muiño MosqueraPaul CouckeBjörn MentenJulie De BackerJolanda van Hengel

A1 Journal Article in STEM CELL RESEARCH