Research Explorer

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Project

Human stem cell-derived models to unveil mechanisms of impaired myocardial function in Marfan Syndrome

Outputs and Outcomes

Publications

Human stem cell models for Marfan syndrome : a brief overview of the rising star in disease modelling

Jeffrey AaldersLaura Muiño MosqueraJolanda van Hengel

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis

Jeffrey AaldersLaurens LégerBehrouz HassanniaVera GoossensTom Vanden BergheJolanda van Hengel

A1 Journal Article in REGENERATIVE THERAPY

Combinatorial effects of surface plasma-treating and aligning PCL/chitosan nanofibers on the behavior of stem cell-derived cardiomyocytes for cardiac tissue engineering

Laurens LégerSheida AliakbarshiraziPegah ZahedifarJeffrey AaldersPascal Van Der VoortNathalie De GeyterRino MorentJolanda van HengelRouba Ghobeira

A1 Journal Article in APPLIED SURFACE SCIENCE

Three-dimensional co-culturing of stem cell-derived cardiomyocytes and cardiac fibroblasts reveals a role for both cell types in Marfan-related cardiomyopathy

Jeffrey AaldersLaurens LégerLouis Van der MeerenSanjay SinhaAndre SkirtachJulie De BackerJolanda van Hengel

A1 Journal Article in MATRIX BIOLOGY

Photoporation-mediated spatial intracellular delivery of stem cell-derived cardiomyocytes

Laurens LégerChloë De ClercqJeffrey AaldersKiara Van Acker-VerbercktKevin BraeckmansJolanda van Hengel

A2 Journal Article in METHODSX

Modelling Marfan-related cardiomyopathy in vitro using human induced pluripotent stem cells

Jeffrey AaldersJolanda van HengelJulie De Backer

Generation of human induced pluripotent stem cell line UGENTi001-A from a patient with Marfan syndrome carrying a heterozygous c.7754 T > C variant in FBN1 and the isogenic control UGENT001-A-1 using CRISPR/Cas9 editing

Jeffrey AaldersLaurens LégerAnthony DemolderLaura Muiño MosqueraPaul CouckeBjörn MentenJulie De BackerJolanda van Hengel

A1 Journal Article in STEM CELL RESEARCH

English

Dutch

English

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