Research Explorer

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Project

Identification of modifier genes underlying the phenotypic variability in the ‘Brittle Bone Disease’, using zebrafish models and patient-derived induced pluripotent stem cells

Outputs and Outcomes

Publications

Bmpr1aa modulates the severity of the skeletal phenotype in an fkbp10-deficient Bruck syndrome zebrafish model

Tamara JaraysehSophie DebaenstHanna De SaffelToon RosseelMauro Alessio MilazzoJan Willem BekDavid M HudsonFilip Van NieuwerburghYannick GansemansIván JosipovicMatthieu BoonePaul Eckhard WittenAndy WillaertPaul Coucke et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract

Tamara JaraysehBrecht GuillemynHanna De SaffelJan Willem BekDelfien SyxSofie SymoensYannick GansemansFilip Van NieuwerburghSujatha JagadeeshJayarekha RajaFransiska MalfaitPaul CouckeAdelbert De ClercqAndy Willaert et al.

A1 Journal Article in HUMAN GENETICS