Research Explorer

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Project

Investigating the effects of regulatory phosphorylation and linear ubiquitination on Pyrin-mediated auto-inflammatory disorders.

Outputs and Outcomes

Publications

Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes

Hannah StocksElisabeth De LeeuwBart LambrechtLinos VandekerckhoveGeert van LooAndy Wullaert

U Journal Article in FRONTIERS IN IMMUNOLOGY

Regulation of inflammasome signaling by the linear deubiquitinase OTULIN

Maria Giulia DoglioAndy WullaertGeert van Loo

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van LooAndy Wullaert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion

Maria Giulia DoglioLien VerboomEmily Ruilova SosorangaUlrika FrisingTomoko AsaokaYannick GansemansFilip Van NieuwerburghGeert van LooAndy Wullaert

A1 Journal Article in SCIENCE IMMUNOLOGY

Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection

Elien EeckhoutLisa HamerlinckVeronique JonckheerePetra Van DammeGeert van LooAndy Wullaert

A1 Journal Article in CELL DEATH & DISEASE

Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice

Ulrika FrisingSilvia Ribó GenéMaria Giulia DoglioBernard MalissenGeert van LooAndy Wullaert

A1 Journal Article in EMBO REPORTS