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Project
Investigating the effects of regulatory phosphorylation and linear ubiquitination on Pyrin-mediated auto-inflammatory disorders.
Information
Project Team
Outputs and Outcomes
Publications
Regulation of inflammasome signaling by the linear deubiquitinase OTULIN
Maria Giulia Doglio
Andy Wullaert
Geert van Loo
Dissertation
2024
The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice
Elien Eeckhout
Tomoko Asaoka
Hanne Van Gorp
Dieter Demon
Charlotte Girard-Guyonvarc'h
Vanessa Andries
Lars Vereecke
Cem Gabay
Mohamed Lamkanfi
Geert van Loo
Andy Wullaert
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2023
Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion
Maria Giulia Doglio
Lien Verboom
Emily Ruilova Sosoranga
Ulrika Frising
Tomoko Asaoka
Yannick Gansemans
Filip Van Nieuwerburgh
Geert van Loo
Andy Wullaert
A1
Journal Article
in
SCIENCE IMMUNOLOGY
2023
Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection
Elien Eeckhout
Lisa Hamerlinck
Veronique Jonckheere
Petra Van Damme
Geert van Loo
Andy Wullaert
A1
Journal Article
in
CELL DEATH & DISEASE
2023
Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice
Ulrika Frising
Silvia Ribó Gené
Maria Giulia Doglio
Bernard Malissen
Geert van Loo
Andy Wullaert
A1
Journal Article
in
EMBO REPORTS
2022