Project

Selective tumor-targeting by quorum-sensing derived peptidic drugs

Code

01J14811

Duration

01 May 2010 → 30 April 2015

Funding

Regional and community funding: Special Research Fund

Promotor

Bart De Spiegeleer

Research disciplines

Natural sciences
- Scientific computing
- Bioinformatics and computational biology
Medical and health sciences
- Bioinformatics and computational biology
- Medical imaging and therapy
- Morphological sciences
- Oncology
- Bioinformatics and computational biology
- Medical imaging and therapy
- Morphological sciences
- Oncology
- Public health care
- Public health services
- Bioinformatics and computational biology
- Medical imaging and therapy
- Morphological sciences
- Oncology
Engineering and technology
- Scientific computing

Keywords

rodent models therapy cell models oncology diagnostics pharmaceutical development peptidic drugs quorum-sensing tumor targeting

Project description

Peptides, derived from quorum-sensing compounds with potential antitumor structural characteristics, are being investigated towards their selective tumor interactions. Their structures are deduced from chemo-/bio-informatics, as well as from own experimental results. After the chemical-pharmaceutical (bio-)analytical characterization of the original and radiotracer-modified molecules, the functionality is being verified in different in-vitro cell-based and in-vivo rodent-based tumor models.