Project

Selective tumor-targeting by quorum-sensing derived peptidic drugs

Code
01J14811
Duration
01 May 2010 → 30 April 2015
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Scientific computing
    • Bioinformatics and computational biology
  • Medical and health sciences
    • Bioinformatics and computational biology
    • Medical imaging and therapy
    • Morphological sciences
    • Oncology
    • Bioinformatics and computational biology
    • Medical imaging and therapy
    • Morphological sciences
    • Oncology
    • Public health care
    • Public health services
    • Bioinformatics and computational biology
    • Medical imaging and therapy
    • Morphological sciences
    • Oncology
  • Engineering and technology
    • Scientific computing
Keywords
rodent models therapy cell models oncology diagnostics pharmaceutical development peptidic drugs quorum-sensing tumor targeting
 
Project description

Peptides, derived from quorum-sensing compounds with potential antitumor structural characteristics, are being investigated towards their selective tumor interactions. Their structures are deduced from chemo-/bio-informatics, as well as from own experimental results. After the chemical-pharmaceutical (bio-)analytical characterization of the original and radiotracer-modified molecules, the functionality is being verified in different in-vitro cell-based and in-vivo rodent-based tumor models.