Project

Does angiopoietin-Tie signaling affect podocyte integrity in kidney glomeruli?

Code
01J01919
Duration
01 October 2019 → 30 July 2024
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Agricultural and food sciences
    • Veterinary anatomy, morphology and (clinical) pathology
Keywords
podocytes kidney glomeruli angiopoietins TIE2-receptor
 
Project description

We recently discovered TIE1 and TIE2 receptor signaling on kidney glomerular podocytes, which are important cells of the glomerular filtration barrier. To investigate if TIE-receptors regulate glomerular integrity, we will investigate the role of this signaling system on podocyte function, i.e. survival, migration, proliferation and permeability. In addition, we will investigate the downstream
signaling pathways regulated by TIE-receptors in podocytes.