Research Explorer

Project

Exploring ultrasound mediated mRNA transfection of lymph nodes and ultrasound-induced tumor ablation as a synergistic anticancer strategy.
Code
3E008215
Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Medical and health sciences
    • Immunology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Immunology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Immunology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
Keywords
HIFU ultrasound cancer vaccination dendritic cell immunotherapy immunogenic cell death microbubbles mRNA
 
Project description
 

This project combines two recent developments in immunotherapy: dendritic cell (DC)-based vaccination and immunogenic cell death (ICD). For this, we will explore high intensity focused ultrasound (HIFU) as a none-invasive means to damage tumor tissue and induce ICD. The immune response will be boosted by immunotherapy using mRNA-loaded microbubbles for ultrasound-triggered delivery of antigen- and adjuvant-mRNA to DCs in vivo.