Project

Study of the alteration of mitochondrial proteomics during S. aureus infection in human epithelial cells

Code

01T02712

Duration

01 February 2013 → 31 October 2014

Funding

Regional and community funding: Special Research Fund

Promotor

Claus Bachert

Research disciplines

Medical and health sciences
- Immunology
- Otorhinolaryngology
- Respiratory medicine
- Immunology
- Microbiology
- Otorhinolaryngology
- Respiratory medicine
- Speech, language and hearing sciences
- Immunology
- Otorhinolaryngology
- Respiratory medicine

Keywords

cell death S. aureus inflammation mitochondria

Project description

The overall goal of this project is to analyze whether S. aureus could modulate mitochondrial biogenesis and cell death in human epithelial cells. Mitochondrial proteins will be analyzed by proteomics approach upon S. aureus infection of epihtelial cells. Next, mitochondrial proteins will be validated by knockdown studies. The consequent inflammatory response will be studied in human nasal mucosa explants.