Code
01T02712
Duration
01 February 2013 → 31 October 2014
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Immunology
- Otorhinolaryngology
- Respiratory medicine
- Immunology
- Microbiology
- Otorhinolaryngology
- Respiratory medicine
- Speech, language and hearing sciences
- Immunology
- Otorhinolaryngology
- Respiratory medicine
Keywords
cell death
S. aureus
inflammation
mitochondria
Project description
The overall goal of this project is to analyze whether S. aureus could modulate mitochondrial biogenesis and cell death in human epithelial cells. Mitochondrial proteins will be analyzed by proteomics approach upon S. aureus infection of epihtelial cells. Next, mitochondrial proteins will be validated by knockdown studies. The consequent inflammatory response will be studied in human nasal mucosa explants.